KMID : 0383820120720020207
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Tuberculosis and Respiratory Diseases 2012 Volume.72 No. 2 p.207 ~ p.211
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A Case of Hemolytic Uremic Syndrome in a Lung Cancer Patient Treated with Gemcitabine
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Pack Yun-Jung
Yang Keun-Suk Jung Hong-Soon Nam Hee-Chul Jung Seung-Hye Kim Boo-Gyoung Kim Ka-Young Kim Jeong-Ho Kim Young-Ok Yun Yu-Seon
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Abstract
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Hemolytic uremic syndrome (HUS) is a rare disorder characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS arises from a wide spectrum of conditions, and chemotherapeutic agents have been reported to be associated with HUS, including Mitomycin, Cisplatin, Bleomycin, and Gemcitabine. A 76-year-old man treated with Gemcitabine due to non-small cell lung cancer developed clinical and laboratory findings compatible with HUS. Gemcitabine was ceased and hemodialysis and plasma exchange were utilized and he recovered. A high level of suspicion for HUS is necessary when cancer patients are treated with Gemcitabine, and prompt recognition and treatment are also essential.
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KEYWORD
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Hemolytic-Uremic Syndrome, Gemcitabine, Lung Neoplasms
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